List of Scientific Publications

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Study of the uptake and bioaccumulation of palladium nanoparticles by Sinapis alba using single particle ICP-MS


Date: 2018
Authors: Kinska, K;Jimenez-Lamana, J;Kowalska, J;Krasnodebska-Ostrega, B;Szpunar, J;
References: Science of The Total Environment 615 1078-1085
Keywords/Products: ICP;ICP-MS;Meinhard;NexION;Perkin Elmer;
In recent years, increased palladium content has been found in the environment, due to its wide use in various fields, especially as catalytic converters. Palladium can be emitted as a range of soluble and insoluble compounds and in the form of palladium nanoparticles (PdNPs). The level of toxicity is equally dependent on concentration and form of palladium and hence, it is important to determine not only the total content of this element, but also its forms of occurrence. This study for the first time investigates the uptake degree and distribution of PdNPs by model plant Sinapis alba, in comparison with a platinum salt (Pd(NO3)2). An enzymatic digestion method which allows the extraction of PdNPs from the different plant tissues without altering their properties was applied. After extraction, samples were analysed by single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) to provide information about the presences of palladium in nanoparticulated or dissolved form, the nanoparticle size and the nanoparticle number concentration. Significant amounts of PdNPs were found even in aboveground organs, but no significant changes in plant morphology were observed. Size distributions of PdNPs found in all tissues presented lower diameters than size distribution of the PdNPs stock suspension, suggesting that bigger nanoparticles are not taken up by the plant. The average size found is in good agreement between the different organs. Moreover, dissolved palladium was found in all samples, with the biggest contribution, in relative terms, observed in leaves followed by stems and roots.

Propagation of sub-atmospheric methyl formate flames


Date: 2018
Authors: Lee, DJ;Burrell, RR;Egolfopoulos, FN;
References: Combustion and Flame 189 24-32
Keywords/Products: Meinhard;TR-50-A3;
Laminar flame speeds of methyl formate/air mixtures were measured at sub-atmospheric pressures for which limited data exist. The experiments were carried out in the counterflow configuration at an unburned mixture temperature of 333 K. The flow velocities were measured using particle image velocimetry. Particle phase slip correction was applied to low-pressure data sets for which the density disparity between the flow tracers and the gaseous phase is notable. The data were modeled using two recently developed kinetic models of methyl formate oxidation, and significant disagreements were realized at all pressures especially under fuel-rich conditions. Additionally, the computed species profiles of CO and CO2 in the burner-stabilized flame configuration using the two models were found to differ significantly. Reaction path analysis revealed that the kinetics of CH2OCHO that is produced directly from the fuel affects the overall reactivity, and the attendant rate constants differ between the two models. The variation of laminar flame speed with pressure revealed also a different behavior between experiments and simulations. Further insight into the sources causing the observed discrepancies were investigated and it was determined that reactions involving formyl radical, methanol, and formaldehyde could also be responsible for the reduction in reactivity specifically under fuel-rich conditions.

Growth, structure and characterization of physico-chemical and magnetic properties of CdCr2Se4: Mn single crystals


Date: 2018
Authors: Jendrzejewska, I;Gron, T;Kusz, J;Goraus, J;Kita, A;Barsova, Z;Slebarski, A;Fijalkowski, M;Pietrasik, E;Zajdel, P;Duda, H;
References: Journal of Alloys and Compounds 735 480-488
Keywords/Products: Concentric;Meinhard;
Crystal structure, magnetic and specific heat measurements, electrical conductivity, as well as DSC/TG measurements for single-crystalline CdxMnyCrzSe4 (where x + y + z ≈ 3) spinels are presented. The electrical conductivity and dc magnetic susceptibility measurements exhibit thermally activated semiconducting properties and ferromagnetic (FM) order for all compositions below the Curie temperature TC = 130 K, respectively. The long-range FM interactions, defined by the Curie temperature, do not substantially depend on the manganese content, and the nearest neighbour FM interactions, represented by the positive value of the Curie-Weiss temperature, decrease from 183 K to 156 K. Hysteresis loops of all crystals have a very small coercive field (˜18 Oe) and remanence (˜0.09 µB/f.u.) with full saturation above 10 kOe. These effects are interpreted in terms of the superexchange integrals for the first two coordination spheres including spin defects.

Ion-pairing reversed-phase chromatography coupled to inductively coupled plasma mass spectrometry as a tool to determine mercurial species in freshwater fish


Date: 2018
Authors: Cheng, H;Chen, X;Shen, L;Wang, Y;Xu, Z;Liu, J;
References: J Chromatogr A 1531 104-111
Keywords/Products: Concentric;Concentric nebulizer;ICP;ICP-MS;Meinhard;Thermo;TR-30-A1;
Most of analytical community is focused on reversed phase high performance liquid chromatography (RP-HPLC) for mercury speciation by employing mobile phases comprising of high salts and moderate amounts of organic solvents. This study aims at rapid mercury speciation analysis by ion-pairing RP-HPLC with inductively coupled plasma mass spectrometry (ICP-MS) detection only using low salts for the sake of green analytical chemistry. Two ion-pairing HPLC methods were developed on individual usage of positively and negatively charged ion-pairing reagents (tetrabutylammonium hydroxide -TBAH and sodium dodecylbenzene sulfonate -SDBS), where sodium 3-mercapto-1-propysulfonate (MPS) and l-cysteine (Cys) were individually added in mobile phases to transform mercury species into negative and positive Hg-complexes for good resolution. Addition of phenylalanine was also utilized for rapid baseline separation in combination of short C18 guard columns. Optimum mobile phases of 2.0mM SDBS+2.0mM Cys+1.0mM Phe (pH 3.0) and 4.0mM TBAH+2.0mM MPS+2.0mM Phe (pH 6.0) both achieved baseline separation of inorganic mercury (Hg2+), methylmercury (MeHg), ethylmercury (EtHg) and phenylmercury (PhHg) on two consecutive 12.5-mm C18 columns. The former mobile phase was selected for mercury speciation in freshwater fish because of short separation time (3.0min). Detection limits of 0.015 for Hg2+, 0.014 for MeHg, 0.028 for EtHg and 0.042 gL-1 for PhHg were obtained along with satisfactory precisions of peak height and area (1.0-2.8% for 5.0 gL-1 Hg-mixture standard). Good accordance of determined values of MeHg and total mercury in certified reference materials of fish tissue (GBW 10029) and tuna fish (BCR-463) with certified values as well as good recoveries (91-106%) proved good accuracy of the proposed method. An example application to freshwater fish indicated its potential in routine analysis, where MeHg was presented at 3.7-20.3 gkg-1 as the dominate species.

Fossil travertines and quasi-travertine in the Minusa basin (West Siberia): structure, composition, and comparative analysis


Date: 2017
Authors: Fedoseev, G;Vorontsov, A;Orekhov, A;
References: Russian Geology and Geophysics 58 922-934
Keywords/Products: Meinhard;
We study a carbonate body looking like a classical fossil travertine which was discovered in the Chebaki-Balakhta basin within the Minusa trough (Khakassia, Russia) and called quasi-travertine. It is a thin layer sandwiched between a basalt-dolerite sill and calcareous siltstone. Comprehensive studies of the quasi-travertine and its comparison with Devonian fossil travertines located a few kilometers away in terms of structure and composition have made the basis for its formation model. According to this model, the quasi-travertine has had a two-stage history: deposition and subsequent hydrothermal metasomatism. Laminated limestone coexisting with calcareous siltstone of the Early Devonian Shunet Formation formed during the first stage and then experienced hydrothermal metasomatism with precipitation of secondary calcite, prehnite, and pyrobitumen (kerite).

Competitive Sorptiong and Transport of heavey metals in soils and geological media


Date: 2017
Authors: Selim, HM;
References: Book
Keywords/Products: Concentric;Concentric nebulizer;Meinhard;


The Analysis of Drinking Water Using Universal Collision-Reaction Gas Technology on the NexION 1000 ICP-MS


Date: 2017
Authors: Kroukamp, EM;Patel, P;Abou-Shakra, F;
References: Product
Keywords/Products: ICP;ICP-MS;Meinhard;NexION;Type C;


87sr/86sr Isotope Ratio And Multielemental Signatures As Indicators Of Origin Of Europeen Cured Hams: The Role Of Salt


Date: 2017
Authors: Epova, EN;Berail, S;Zuliani, T;Malherbe, J;Sarthou, L;Valiente, M;Donard, OF;
References: Food Chemistry 246 313-322
Keywords/Products: ICP;ICP-MS;Meinhard;NexION;
We have examined the potential of discriminant inorganic constituents (trace-, ultra-trace elements and Sr isotope ratios) to assess the origin of world famous brands of European dry-cured hams. The variation of the multielemental composition with principal component analysis allowed to discriminate the origin of Bayonne hams. Determined ratio 87Sr/86Sr was recognized as a strong additional distinctive parameter. The ratio 87Sr/86Sr allowed to better separate all the different categories of hams in addition to the multi-elemental detection. The major contribution of the value 87Sr/86Sr for the Bayonne ham is directly related to its curing due to the salt used in process coming from the nearby salt mine Salies-de-Bearn. Since the salt represents around 4% of the final product, it will therefore strongly influence the elemental and isotopic composition of hams. The overall discrimination potential of strontium isotope ratio is evidenced in the final statistical discrimination of the origin of hams.

Extraction of Iodine from Source Rock and Oil for Radioiodine Dating Final Report CRADA No. TC-1550-98


Date: 2017
Authors: Moran, JE;Summa, L;
References: Report
Keywords/Products: Meinhard;


How traces of pollutants in the environment modify bioremediation efficiency performed with Desulfovibrio vulgaris, and the advantage of an optimization protocol using soft chemicals


Date: 2017
Authors: Rampazzo, M;Manente, S;Micheluz, A;Ganzerla, R;Ravagnan, G;
References: Journal of Cultural Heritage
Keywords/Products: Concentric;ICP;ICP-AES;ICP-MS;Meinhard;Optima;
In recent years, Desulfovibrio vulgaris has been used to clean marble statues affected by gypsum black crusts. Many studies showed that 'biocleaning' is very selective: chemical-cleaning products cannot distinguish the decay product, which has to be eliminated, from the original stone that must be fully preserved. Besides, they may cause direct and indirect damage to limestone artefacts. Instead, Sulphate Reducing Bacteria (SRB), as D. vulgaris, are able to remove just the decay matter. D. vulgaris uses SO42- ions (gypsum constituent) in its own respiratory chain; while, it does not interact with the calcium carbonate layer underneath because it does not need carbonate ions for its catabolism. However, 'biocleaning' shows a large variability in the efficiency depending on the environment. If the cleaning results are not consistent, 'biocleaning' cannot become an alternative cleaning method. Therefore, it is extremely important to uncover the reasons behind these differences, and to identify possible strategies to overcome the problem. The large variability of efficiency of 'biocleaning' can be explained by the close relationship between the bacterial community and pollutants previously entrapped in the substrate. The aim of this work is to ascertain this hypothesis and identify how the toxic effects of the inorganic pollutants could be mitigated to improve the efficiency of this new cleaning method. In order to identify which kinds of pollutants were present and how they interact with the bacterial community during 'biocleaning', two different steps have been carried out. The first step consists in an environmental/ecotoxicological study that characterized the substrate and proves if inorganic pollutants could affect the bacterial survival. Toxic heavy metals were found into the chalky matrix by ICP-AES and ICP-MS analyses and the followed toxicological kinetic studies demonstrated that they reduced the bacterial growth and activity. The second step consists of an optimization of the in situ bioremediation protocol, to create a better condition for the 'biocleaning' application. A soft chemical pre-treatment was performed before the bacterial application using Tween 20 surfactant. Tween 20 (non-ionic surfactant) was able to reduce the adverse effects of pollutants, decreasing their superficial amount. Moreover, the method did not influence bacterial growth and activity since it did not have superficial charges and it did not change the pH value of the surroundings. This work proves that inorganic pollutants present in the gypsum decay layer can drastically reduce the bacterial growth and, at the same time, they decrease heavily the bioremediation efficiency. This study provides a soft chemical optimization strategy, helping to overcome the problem and to improve the 'biocleaning' efficiency.

Protective effect of selenium supplementation following oxidative stress mediated by glucose on retinal pigment epithelium


Date: 2017
Authors: Gonzalez de Vega, R;Garcia, M;Fernandez-Sanchez, ML;Gonzalez-Iglesias, H;Sanz-Medel, A;
References: Metallomics
Keywords/Products: ICP;ICP-MS;Meinhard;sample introduction;
There are many conditions that affect the retina. However, diabetic retinopathy (RD) as a complication of Diabetes Mellitus continues to be the leading cause of blindness in working people globally. Diabetic retinopathy is an ocular complication of diabetes that is caused by the deterioration of the blood vessels that supply the retina, which has the consequence that the vision deteriorates irreversibly. The retina, and specifically the retinal pigment epithelium (RPE) is the only neural tissue that is exposed directly and frequently to light, which favors the oxidation of lipids that become extremely toxic to the cells of the retina. The RPE is a natural barrier playing an important role in the absorption of light and reduction of light scatter within the eye. In addition, the retina is the tissue that proportionally consumes more oxygen, which generates a high production of reactive oxygen species (ROS). The retina is particularly sensitive to hyperglycemia and oxidative stress. The eye tissues are enriched in certain antioxidants in the form of metabolic enzymes or small molecules. Since selenium is essential for regulating the activity of the enzymes involved in protection against oxidative stress, providing selenium to the ocular tissues could be useful for the treatment of different ocular pathologies. Thus, the aim of this study is to investigate the potential efficacy of selenium in human RPE against glucose-induced oxidative stress and its implications for GPx activity. Chromatographic techniques based on HPLC-ICP-MS will be applied in combination with isotope pattern deconvolution (IPD) to study the effects of selenium supplementation and hyperglycemia in an in vitro model of RPE cells.

Zr precipitation kinetics in irradiated fuel dissolution solution by TIMS and ICP-MS: a combined study


Date: 2017
Authors: Baghdadi, S;Quemet, A;Esbelin, E;Manidren, Y;Gracia, S;Dalier, V;Poinsignon-Jacquemin, R;Huyghe, L;Buravand, E;Dautheribes, J;Rivier, C;
References: Journal of Radioanalytical and Nuclear Chemistry 314 2377-2382
Keywords/Products: Concentric;ICP;ICP-MS;Meinhard;Thermo;
This study presents the combined analysis of leftover zirconium in irradiated fuel dissolution solution through time. Thermo-ionisation mass spectrometry was used to analyse the kinetics start and final aliquots with uncertainties lower than 3%, while inductively coupled plasma-mass spectrometry (ICP-MS) was used for intermediary aliquots. In order to obtain low uncertainties using ICP-MS, dissolution solutions were spiked with lutetium, used as a process tracer, in order to perform a relative analysis. The analytical parameters were optimised and uncertainties were lower than 3% for real nuclear samples. This method shows the input of ICP-MS for concentration evolutions determination.

Assessing the bioavailability and bioaccessibility of total arsenic and arsenic species in environmental samples


Date: 2017
Authors: PIZARRO, I;ROMAN, D;GOMEZ, M;PALACIOS, MA;
References: Journal of the Chilean Chemical Society 62 3653-3657
Keywords/Products: Glass Nebulizer;ICP;ICP-MS;Meinhard;
Studies on the bioavailability of As, of impacted vegetables; and As bioaccesibility in the edible parts of carrots (daucus carota), beets (beta vulgaris) and quinoa (chenopodium) growing in polluted soils thought 'in vitro' gastrointestinal process; the As speciation both in the edible parts of vegetables and in their gastrointestinal extracts have been performed. Elemental analysis and As speciation have been performed by ICP-MS and LC-ICP-MS, respectively. The Arsenic recovery after the in vitro gastrointestinal digestion was from 98, 90 and 40% for carrots, beets and quinoa, respectively; with no significant transformation of original As species. These studies provide a clearer understanding of the impact that As and other contaminant elements may present in the population of this high polluted Chilean region.

Entwicklung und Charakterisierung eines Pikoliter - Dosiersystems fur Kalibrierungen in der induktiv gekoppelten Plasma - Massenspektrometrie in Verbindung mit der Laserablation


Date: 2017
Authors: Petersen, JH;
References: Thesis
Keywords/Products: HEN;Meinhard;


Aerosol-Phase Extraction Method for Determination of Ca, K, Mg, and Na in Biodiesel through Inductively Coupled Plasma Optical Emission Spectrometry


Date: 2017
Authors: Sanchez, R;Maestre, S;Prats, S;Todoli, JL;
References: Anal. Chem. 89 13618-13625
Keywords/Products: Aerosol;Concentric;Concentric nebulizer;ICP;ICP-OES;Meinhard;TR-30-A2;
A novel extraction method was developed, optimized, and validated for the elemental analysis of organic samples. The method, called aerosol-phase extraction (APE), is based on nebulization of the extracting aqueous solution (0.1 mol L-1 nitric acid) on the sample. Extraction was performed at the interface of generated extractant droplets as they entered into contact with the samples. Afterward, the phases were allowed to separate and Ca, K, Na, and Mg were determined in aqueous phase by means of inductively coupled plasma optical emission spectroscopy (ICP-OES). Measurement of aerosol characteristics demonstrated that a water-in-oil emulsion was generated. Therefore, once the aqueous solution was dispersed into the sample, the phases spontaneously separated. Furthermore, the interfacial specific surface area exhibited values on the order of 1 m2 mL-1, hence enhancing the extraction kinetics over conventional extraction methods. Key variables affecting the extraction yield were the nebulization gas flow rate, liquid flow rate, extraction time, acid concentration, nebulizer tip to sample surface gap, and morg/maq ratio. Once the optimal conditions were selected, the method was applied and validated for the determination of Ca, K, Na, and Mg by ICP-OES in 0.5 mL biodiesel samples with an expanded uncertainty lower than 2%. With the APE method, the extraction time was around 1 min, whereas conventional methods employed to perform this kind of extraction required from 4 to 50 min. Additionally, the APE involved preconcentration of analytes, thus lowering the limit of detection (LOD) to the nanograms per milliliter level (i.e., LODs based on the 3sb criterion were 32, 20, 19, and 24 ng mL-1 for Ca, K, Na, and Mg, respectively). Furthermore, accuracy of quantification of Ca, K, Na, and Mg concentration by APE was not significantly different as compared to that afforded by conventional liquid-liquid extraction. Finally, Ca, K, Na, and Mg contents were determined in four real samples in the 0.5-13 mg kg-1 range. The obtained results were not statistically different from those encountered with a microwave-based digestion method.

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation


Date: 2017
Authors: Davey, GE;Adhireksan, Z;Ma, Z;Riedel, T;Sharma, D;Padavattan, S;Rhodes, D;Ludwig, A;Sandin, S;Murray, BS;Dyson, PJ;Davey, CA;
References: Nat Commun 8 1575
Keywords/Products: ELAN;ICP;ICP-MS;Meinhard;Perkin Elmer;
The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous molecules remains unclear. Here, we characterize a family of binuclear ruthenium compounds that selectively target the nucleosome acidic patch, generating intra-nucleosomal H2A-H2B cross-links as well as inter-nucleosomal cross-links. In contrast to cisplatin or the progenitor RAPTA-C anticancer drugs, the binuclear agents neither arrest specific cell cycle phases nor elicit DNA damage response, but rather induce an irreversible, anomalous state of condensed chromatin that ultimately results in apoptosis. In vitro, the compounds induce misfolding of chromatin fibre and block the binding of the regulator of chromatin condensation 1 (RCC1) acidic patch-binding protein. This family of chromatin-modifying molecules has potential for applications in drug development and as tools for chromatin research.

Sources and distribution of yttrium and rare earth elements in surface sediments from Tagus estuary, Portugal.


Date: 2017
Authors: Brito, P;Prego, R;Mil-Homens, M;Cacador, I;Caetano, M;
References: Sci. Total Environ. 621 317-325
Keywords/Products: Concentric;ICP;ICP-MS;Meinhard;Thermo;
The distribution and sources of yttrium and rare-earth elements (YREE) in surface sediments were studied on 78 samples collected in the Tagus estuary (SW Portugal, SW Europe). Yttrium and total REE contents ranged from 2.4 to 32mg kg-1 and 18 to 210mg kg-1, respectively, and exhibited significant correlations with sediment grain-size, Al, Fe, Mg and Mn, suggesting a preferential association to fine-grained material (e.g. aluminosilicates but also Al hydroxides and Fe oxyhydroxides). The PAAS (Post-Archean Australian Shale) normalized patterns display three distinct YREE fractionation pattern groups along the Tagus estuary: a first group, characterized by medium to coarse-grained material, a depleted and almost flat PAAS-normalized pattern, with a positive anomaly of Eu, representing one of the lithogenic components; a second group, characterized mainly by fine-grained sediment, with higher shale-normalized ratios and an enrichment of LREE relative to HREE, associated with waste water treatment plant (WWTP) outfalls, located in the northern margin; and, a third group, of fine-grained material, marked by a significant enrichment of Y, a depletion of Ce and an enrichment of HREE over LREE, located near an inactive chemical-industrial complex (e.g. pyrite roast plant, chemical and phosphorous fertilizer industries), in the southern margin. The data allow the quantification of the YREE contents and its spatial distribution in the surface sediments of the Tagus estuary, identifying the main potential sources and confirming the use of rare earth elements as tracers of anthropogenic activities in highly hydrodynamic estuaries.

Arsenic, cadmium and lead concentrations in Yerba mate commercialized in Southern Brazil by inductively coupled plasma mass spectrometry


Date: 2017
Authors: Santos, LM;Neto, SA;Iozzi, G;Jacob, Sd;
References: Ciencia Rural 47
Keywords/Products: Concentric;Concentric nebulizer;Glass Nebulizer;ICP;ICP-MS;Meinhard;NexION;Perkin Elmer;
Mate or 'Yerba Mate' (Ilex paraguariensis) is a native South American plant, commonly consumed in Argentina, Paraguay, Uruguay and southern Brazil. Recent research has detected the presence of many vitamins and metals in this plant. These metals are also part of yerba mate's mineral composition, due to soil and water contamination by pesticides and fertilizers, coal and oil combustion, vehicle emissions, mining, smelting, refining and the incineration of urban and industrial waste. Regardless of their origin, some inorganic elements, such as arsenic, cadmium and lead, are considered toxic, since they accumulate in all plant tissues and are, thus, introduced into the food chain. In this context, the aim of the present study was to determine and compare arsenic, cadmium, lead concentrations in 104 samples of yerba mate (Ilex paraguariensis) marketed, and consumed in three southern Brazilian States, namely Parana (PR), Santa Catarina (SC) and Rio Grande do Sul (RS). Each element was determined by inductively coupled plasma mass spectrometry (ICP-MS), on a Nexion 300D equipment (Perkin Elmer). As, Cd and Pb concentrations in yerba mate leaves ranged from 0.015 to 0.15mg kg-1, 0.18 to 1.25mg kg-1 and 0.1 to 1.20mg kg-1, respectively. Regarding Cd, 84% of the samples from RS, 63% from PR and 75% from SC showed higher concentrations than the maximum permissible limit of 0.4mg kg-1 established by the Brazilian National Sanitary Surveillance Agency (ANVISA), while 7% of the samples from RS and 5% from PR were unsatisfactory for Pb. Concentrations were below the established ANVISA limit of 0.6mg kg-1 for all samples.

Preliminary Survey of Matrix effects in the Microwave-sustained, Inductively Coupled Atmospheric-pressure Plasma (MICAP)


Date: 2017
Authors: Thaler, KM;Schwartz, AJ;Haisch, C;Niessner, R;Hieftje, GM;
References: Talanta 180 25-31
Keywords/Products: Concentric;Concentric nebulizer;Meinhard;
Matrix effects caused by Na and Al in the nitrogen Microwave-sustained, Inductively Coupled, Atmospheric-pressure Plasma (MICAP) were investigated. Easily ionizable elements, such as Na, can suppress or enhance the analyte signal; Al is shown here to produce a similar effect. The influence of these matrices was examined for 18 emission lines of 8 analyte atoms and ions having a wide range of excitation and ionization energies. The plasma operating conditions were fixed during all experiments at a total nitrogen flow of 19.4 L min-1 and a microwave power of 1.5 kW. An Fe solution was used to determine the excitation temperature of the plasma by the Boltzmann plot method at selected matrix concentrations. In addition, vertical emission profiles of the plasma were measured. The matrix effect becomes worse at higher concentrations of an easily ionizable element. The effect is caused not only by a shift in ionization equilibrium but also by a possible change in plasma ionization temperature. Correction methods to reduce the matrix effects were tested and are discussed.

Activity evaluation and toxicological profile of new potential 'Metal Protein Attenuating Compounds' in biological models of Alzheimer's disease


Date: 2017
Authors: Rey, NA;
References: Thesis
Keywords/Products: Meinhard;





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